Diabetologia. 2025 May 10. doi: 10.1007/s00125-025-06434-2. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Efficient prediction of clinical type 1 diabetes is important for risk stratification and monitoring of autoantibody-positive individuals. In this study, we compared type 1 diabetes predictive
Diabetologia. 2025 May 7. doi: 10.1007/s00125-025-06442-2. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: This study aimed to compare the ability of time in tight range (TITR) and time in range (TIR) to predict the achievement of typical glucose management indicator (GMI) and HbA1c targets.METHODS:
No abstractDiabetologia. 2025 May 5. doi: 10.1007/s00125-025-06435-1. Online ahead of print.NO ABSTRACTPMID:40323333 | DOI:10.1007/s00125-025-06435-1
Diabetologia. 2025 May 2. doi: 10.1007/s00125-025-06439-x. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Our aim was to assess treatment discontinuation, reinitiation and switching between drugs within the same drug class for glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotr
Diabetologia. 2025 May 2. doi: 10.1007/s00125-025-06428-0. Online ahead of print.ABSTRACTThis review describes a prolonged research endeavour to test the twin cycle hypothesis that type 2 diabetes is caused by fat-induced dysfunction of the liver and pancreas, guided by the happenstance of clinical
Diabetologia. 2025 May 2. doi: 10.1007/s00125-025-06441-3. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Findings from RCTs and observational studies indicate a positive association between statin use and risk of type 2 diabetes. Mendelian randomisation studies provide evidence to support that the
Diabetologia. 2025 Apr 30. doi: 10.1007/s00125-025-06431-5. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: The endoplasmic reticulum (ER) stress-induced unfolded protein response helps determine beta cell survival rate in diabetes. The alternative eukaryotic translation initiation factor 2A (EIF2A)
Diabetologia. 2025 Apr 30. doi: 10.1007/s00125-025-06429-z. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Individuals with type 1 diabetes are at increased cardiovascular risk, particularly in the presence of insulin resistance. A prothrombotic environment is believed to contribute to this risk but
Diabetologia. 2025 Apr 29. doi: 10.1007/s00125-025-06440-4. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Soluble receptor for advanced glycation end products (sRAGE) has been inversely linked to obesity, which is defined by excess of total body fat. However, body fat accumulation is also relevant
No abstractDiabetologia. 2025 Apr 29. doi: 10.1007/s00125-025-06418-2. Online ahead of print.NO ABSTRACTPMID:40298966 | DOI:10.1007/s00125-025-06418-2
Diabetologia. 2025 Apr 28. doi: 10.1007/s00125-025-06436-0. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Disrupted energy balance is critical for the onset and development of type 2 diabetes mellitus. Understanding of the exact underlying metabolic mechanisms remains incomplete, but skeletal muscl
Diabetologia. 2025 Apr 28. doi: 10.1007/s00125-025-06432-4. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Excessive endoplasmic reticulum (ER) stress in beta cells can impair proliferation and contribute to autoimmune responses such as the destruction of beta cells in type 1 diabetes. Exocrine-beta
Diabetologia. 2025 Apr 24. doi: 10.1007/s00125-025-06438-y. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: It has been proposed that severe hypoglycaemia events (SHE) may increase the risk of adverse CVD complications in adults with type 1 diabetes. The aim of this study was to evaluate the risk of
Diabetologia. 2025 Apr 23. doi: 10.1007/s00125-025-06427-1. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Diabetic peripheral neuropathy (DPN) and neuropathic pain (NP) are common complications of type 1 diabetes that can greatly affect quality of life. Studying DNA methylation (DNAm) may help iden
Diabetologia. 2025 Apr 23. doi: 10.1007/s00125-025-06424-4. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: The role of regulatory factor X 3 (RFX3) in human pancreatic islet development has not been explored. This study aims to investigate the function of RFX3 in human pancreatic islet development u
CONCLUSIONS/INTERPRETATION: A low eGFR(cyst)/eGFR(creat) ratio is independently associated with mortality in type 2 diabetes, including in people without conventional markers of diabetic kidney disease. The presence of SPS may add clinical value to the risk assessment of people with type 2 diabetes
Diabetologia. 2025 Apr 15. doi: 10.1007/s00125-025-06406-6. Online ahead of print.ABSTRACTBoth the global prevalence of diabetes and the frequency of natural and man-made disasters are increasing. Of all chronic diseases, the consequences of sudden loss of medical supplies are most serious for those
Diabetologia. 2025 Apr 12. doi: 10.1007/s00125-025-06426-2. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Inflammation-driven pancreatic beta cell death is a hallmark of type 1 diabetes progression. We have previously shown that serum obtained from individuals after high-intensity interval training
No abstractDiabetologia. 2025 Jun;68(6):1352-1354. doi: 10.1007/s00125-025-06422-6. Epub 2025 Apr 12.NO ABSTRACTPMID:40220192 | PMC:PMC12069405 | DOI:10.1007/s00125-025-06422-6
Diabetologia. 2025 Jun;68(6):1315-1328. doi: 10.1007/s00125-025-06405-7. Epub 2025 Apr 11.ABSTRACTAIMS/HYPOTHESIS: Epidemiological studies indicate that type 2 diabetes increases the risk for Alzheimer's disease. Alterations in cerebral metabolism have been proposed as a potential mechanism underlyi
Diabetologia. 2025 Apr 10. doi: 10.1007/s00125-025-06420-8. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Low birthweight infants are at increased risk not only of mortality, but also of type 2 diabetes mellitus and CVD in later life. At the opposite end of the spectrum, high birthweight infants ha
Diabetologia. 2025 Apr 10. doi: 10.1007/s00125-025-06423-5. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Diabetic ketoacidosis remains a severe complication in type 1 diabetes, arising from insufficient insulin levels and accelerated lipolytic rate, leading to increased β-oxidation of NEFA and ket
Diabetologia. 2025 Apr 5. doi: 10.1007/s00125-025-06419-1. Online ahead of print.ABSTRACTResulting from a combination of genetic and environmental factors, type 2 diabetes is highly heterogeneous in manifestation and disease progression, with the only common feature being chronic hyperglycaemia. In
Diabetologia. 2025 Apr 5. doi: 10.1007/s00125-025-06421-7. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Women with prior gestational diabetes mellitus (GDM) have higher incidence of age-associated diseases, including type 2 diabetes, CVD and cognitive impairment. Human studies cannot readily deter
