J Am Heart Assoc. 2025 May 15:e037100. doi: 10.1161/JAHA.124.037100. Online ahead of print.ABSTRACTBACKGROUND: Weight reduction through lifestyle, activity, and dietary interventions are the mainstay of initial therapy for metabolic dysfunction associated steatotic liver disease. Data on the relativ
Front Pharmacol. 2025 Apr 30;16:1599641. doi: 10.3389/fphar.2025.1599641. eCollection 2025.ABSTRACTBACKGROUND: Infantile epileptic spasm syndrome (IESS), a rare age-specific epileptic encephalopathy, exhibits limited therapeutic efficacy, with approximately 50% of patients showing resistance to adre
Front Immunol. 2025 Apr 30;16:1565158. doi: 10.3389/fimmu.2025.1565158. eCollection 2025.ABSTRACTRegulatory B cells (Bregs) are pivotal modulators of immune tolerance, suppressing inflammation through cytokine secretion and cellular interactions. Their role is particularly significant in inflammator
Cardiovasc Diabetol. 2025 May 14;24(1):210. doi: 10.1186/s12933-025-02747-z.ABSTRACTBACKGROUND: Maintaining optimal glucose control is critical for postoperative care cardiac surgery patients. Continuous glucose monitoring (CGM) in this setting remains understudied. We evaluated the efficacy of CGM
Eur Respir Rev. 2025 May 14;34(176):240220. doi: 10.1183/16000617.0220-2024. Print 2025 Apr.ABSTRACTINTRODUCTION: The Montreal Cystic Fibrosis Related Diabetes Screening Cohort (MCFC) was established in 2004 to study the prevalence, risk factors and management of cystic fibrosis-related diabetes, a
Biochim Biophys Acta Mol Cell Biol Lipids. 2025 May 12:159628. doi: 10.1016/j.bbalip.2025.159628. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is a prevalent and progressive liver disorder posing a global health challenge. Oroxylin A, a naturally occurring flavonoid, with
Wiad Lek. 2025;78(4):797-805. doi: 10.36740/WLek/202970.ABSTRACTOBJECTIVE: Aim: To examine potential protective effect of Tirzepatide against obesity-induced metabolic dysfunction and hepatic inflammatory and apoptotic responses.PATIENTS AND METHODS: Materials and Methods: A total of 28 adult male S
Cell Rep. 2025 May 13;44(5):115691. doi: 10.1016/j.celrep.2025.115691. Online ahead of print.ABSTRACTUsing in vitro models of lipotoxicity and islets from the db/db mouse model of type 2 diabetes (T2D), we show that endoplasmic reticulum (ER) stress impairs β cell function. This is unrelated to apop
J Peripher Nerv Syst. 2025 Jun;30(2):e70026. doi: 10.1111/jns.70026.ABSTRACTBACKGROUND: Hyperglycemia is a major driver of diabetic peripheral neuropathy (DPN) in type 1 diabetes mellitus (T1DM). Advanced hybrid closed-loop (AHCL) technologies improve glycemic control and reduce glycemic variability
Food Funct. 2025 May 14. doi: 10.1039/d5fo00128e. Online ahead of print.ABSTRACTDiabetes mellitus is a chronic metabolic disorder marked by insulin deficiency and hyperglycemia. At present, pharmacotherapy involving synthetic diabetic agents is widely used, but it comes with side effects. In contras
Tidsskr Nor Laegeforen. 2025 May 6;145(6). doi: 10.4045/tidsskr.24.0396. Print 2025 May 13.ABSTRACTAwareness of post-bariatric hypoglycaemia has increased in recent years. The condition appears to be more prevalent than previously estimated, when mild to moderate cases are taken into account. Most p
Front Psychiatry. 2025 Apr 29;16:1537442. doi: 10.3389/fpsyt.2025.1537442. eCollection 2025.ABSTRACTINTRODUCTION: It is increasingly recognized that the brain continuously interacts with other body systems such as the immune system, the gut-brain axis, and the endocrine system. Dysfunctions in these
Niger Postgrad Med J. 2025 Apr 1;32(2):97-103. doi: 10.4103/npmj.npmj_55_25. Epub 2025 May 14.ABSTRACTBACKGROUND: Diabetes mellitus is a chronic illness that commonly leads to progressive and incapacitating of patients' condition over the past 20 years.AIM: The aim of the study was to evaluate the e
J Clin Med. 2025 May 6;14(9):3230. doi: 10.3390/jcm14093230.ABSTRACTObjectives: This study compared the efficacy of continuous insulin infusion therapy (CIT) versus standard bolus insulin therapy in maintaining optimal perioperative glycemic control in patients with type 2 diabetes mellitus (T2DM) u
J Clin Med. 2025 Apr 29;14(9):3083. doi: 10.3390/jcm14093083.ABSTRACTCardiovascular diseases and cancer are the two primary causes of mortality worldwide. Although traditionally regarded as distinct pathologies, they share numerous pathophysiological mechanisms and risk factors, including chronic in
Molecules. 2025 Apr 30;30(9):1991. doi: 10.3390/molecules30091991.ABSTRACTType 2 diabetes mellites (T2DM) is the most common form of diabetes and affects a significant portion of the population. Obesity-related increases in free fatty acids and glucose in the diet contribute to β-cell dysfunction an
Nutrients. 2025 Apr 29;17(9):1511. doi: 10.3390/nu17091511.ABSTRACTBackground: Sarcopenic obesity, characterized by excess fat and reduced muscle mass/function, is linked to chronic inflammation and metabolic dysfunction. Methods: This study aimed to evaluate the efficacy of a 2-month multidisciplin
Nutrients. 2025 Apr 29;17(9):1498. doi: 10.3390/nu17091498.ABSTRACTBACKGROUND/OBJECTIVES: Metabolic syndrome (MetS) is a prevalent health condition characterized by central obesity, insulin resistance, hypertension, and dyslipidemia, increasing the risk of cardiovascular disease and type 2 diabetes.
Nutrients. 2025 Apr 28;17(9):1487. doi: 10.3390/nu17091487.ABSTRACTPediatric obesity is associated with a wide range of comorbidities beyond metabolic changes, affecting cardiovascular, endocrine, reproductive, musculoskeletal systems, and also mental health. Hypertension, commonly observed in child
Nutrients. 2025 Apr 25;17(9):1437. doi: 10.3390/nu17091437.ABSTRACTBackground: Amyotrophic lateral sclerosis (ALS) is a prevalent neurodegenerative disease but lacks effective treatments. Dietary interventions, notably the Mediterranean diet, promise to modulate disease pathways. This study aimed to
Nutrients. 2025 Apr 22;17(9):1404. doi: 10.3390/nu17091404.ABSTRACTBackground/Objectives: High-intensity interval training (HIIT) and time-restricted feeding (TRF) have shown potential in enhancing glucose metabolism, increasing insulin sensitivity, and promoting muscle health. This study investigat
Int J Mol Sci. 2025 May 6;26(9):4417. doi: 10.3390/ijms26094417.ABSTRACTType 2 diabetes mellitus (T2DM) is a chronic metabolic disorder with a high prevalence and challenging treatment options. It significantly affects the function of various organs, including bones, and imposes substantial social a
(Proline3)PP, or (P³)PP, is an enzymatically stable, neuropeptide Y4 receptor (NPY4R)-selective, pancreatic polypeptide (PP) analogue with established weight-lowering and pancreatic islet morphology benefits in obesity-diabetes. In the current study, we now investigate the impact of twice-daily (P³)
Int J Mol Sci. 2025 Apr 29;26(9):4212. doi: 10.3390/ijms26094212.ABSTRACTGlucocorticoid-induced diabetes is the most common form of drug-induced hyperglycemia. In addition, chronic exposure to glucocorticoids promotes lean mass loss and fat mass accumulation. In this study, we hypothesized that a hi
