Diabetes. 2025 Apr 24:db250066. doi: 10.2337/db25-0066. Online ahead of print.ABSTRACTGlucokinase activators (GKA) are a long-sought therapeutic modality for the treatment of Type 2 Diabetes (T2D). However, all GKAs failed clinical trials, with the recent exception of dorzagliatin (Hua Medicine). A
Diabetes. 2025 Apr 24:db250110. doi: 10.2337/db25-0110. Online ahead of print.ABSTRACTPancreatic β-cell KATP channel closure underlies electrical excitability and insulin release, but loss or inhibition of KATP channels can lead to paradoxical crossover from hyperinsulinism plus hypoglycemia, to glu
Diabetes. 2025 Apr 24:db240923. doi: 10.2337/db24-0923. Online ahead of print.ABSTRACTWe tested genetic variants in GCK, GCKR, and PNPLA3 for association with type 2 diabetes-related phenotypes under the hypothesis they may regulate metabolic balance across the liver and contribute to hepatic steato
Diabetes. 2025 Apr 24:db241158. doi: 10.2337/db24-1158. Online ahead of print.ABSTRACTDiabetes is a metabolic disorder associated with an increased risk of systemic vascular complications. Notably, diabetic retinopathy (DR) represents a major microvascular complication and a leading cause of blindne
Diabetes. 2025 Apr 24:db241103. doi: 10.2337/db24-1103. Online ahead of print.ABSTRACTWe aimed to identify distinct axes of obesity using advanced MRI-derived phenotypes. We used 24 MRI-derived fat distribution and muscle volume measures (UK Biobank, n= 33,122) to construct obesity axes through prin
No abstractDiabetes. 2025 Apr 24:dbi250023. doi: 10.2337/dbi25-0023. Online ahead of print.NO ABSTRACTPMID:40272280 | DOI:10.2337/dbi25-0023
Diabetes. 2025 Apr 24:db250037. doi: 10.2337/db25-0037. Online ahead of print.ABSTRACTIslet cell replacement therapies have evolved as a viable treatment option for type 1 diabetes complicated by problematic hypoglycemia and glycemic lability. Refinements of islet manufacturing, islet transplantatio
Diabetes. 2025 Apr 24:db250097. doi: 10.2337/db25-0097. Online ahead of print.ABSTRACTThe identification of a "rundlichen Häuflein" by Paul Langerhans more than 150 years ago marked the initiation of a global effort to unravel the mysteries of pancreatic islets, an intricate system of nutrient-sensi
Diabetes. 2025 Apr 24:db250017. doi: 10.2337/db25-0017. Online ahead of print.ABSTRACTCardiovascular disease (CVD) is a leading cause of morbidity and mortality in individuals with diabetes. Individuals with type 1 diabetes have a two- to fourfold higher risk of CVD in comparison with the general po
Diabetes. 2025 Apr 24:db250042. doi: 10.2337/db25-0042. Online ahead of print.ABSTRACTIn the last two decades, significant progress has been made toward understanding the genetic basis of type 2 diabetes. An important supporter of this research has been the National Institute of Diabetes and Digesti
Diabetes. 2025 Apr 24:db250039. doi: 10.2337/db25-0039. Online ahead of print.ABSTRACTThis year marks the 75th anniversary of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health. NIDDK's long history of research and innovation includes su
Diabetes. 2025 Apr 23:db240737. doi: 10.2337/db24-0737. Online ahead of print.ABSTRACTG protein-coupled receptor 35 (GPR35) is a poorly characterized receptor with unclear intracellular mechanisms in endothelial cells (ECs). Oxidative stress responsive 1 (OXSR1) is a serine/ threonine protein kinase
Diabetes. 2025 May 1;74(5):668-671. doi: 10.2337/dbi24-0049.ABSTRACTIn this month's Classics in Diabetes featured article, published in Diabetes in 1993, the description by Kahn et al. of the relationship between insulin secretion and insulin sensitivity in 93 healthy adults without diabetes provide
No abstractDiabetes. 2025 May 1;74(5):665. doi: 10.2337/dbi25-0015.NO ABSTRACTPMID:40258162 | DOI:10.2337/dbi25-0015
Diabetes. 2025 Apr 18:db240739. doi: 10.2337/db24-0739. Online ahead of print.ABSTRACTOxidative stress has a major pathogenic role in diabetic retinopathy, and neuroretina dysfunction is recognized as an early and important problem. Soluble guanylate cyclase (sGC) has been implicated for its neuropr
Diabetes. 2025 Apr 8:dbi240041. doi: 10.2337/dbi24-0041. Online ahead of print.ABSTRACTGestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy. It is generally defined as glucose intolerance with onset or first recognition during pregnancy. The pathogenesis o
Diabetes. 2025 Apr 4:db240606. doi: 10.2337/db24-0606. Online ahead of print.ABSTRACTGlycated haemoglobin (HbA1c) has shown disagreements with other glycaemic indices; termed the glycation gap. The glycation gap can be influenced by non-glycaemic factors like protein deglycation, through the fructos
Diabetes. 2025 Apr 4:db240121. doi: 10.2337/db24-0121. Online ahead of print.ABSTRACTPathological signaling via the receptor for advanced glycation end-products (RAGE) is critical in diabetic kidney disease (DKD) development, while RAGE deletion is reno-protective. Non-coding RNAs (ncRNAs), includin
Diabetes. 2025 Apr 2:db241000. doi: 10.2337/db24-1000. Online ahead of print.ABSTRACTSince little is known about the disposition index (DI) in autoantibody-positive individuals, we have assessed whether DI has a similar association between insulin secretion and resistance to the association observed
Diabetes. 2025 Apr 2:db250096. doi: 10.2337/db25-0096. Online ahead of print.ABSTRACTActivation of GPR119 receptors, expressed on enteroendocrine and pancreatic islet cells, augments glucagon counterregulatory responses to hypoglycemia in pre-clinical models. We hypothesized that MBX-2982, a GPR119
Diabetes. 2025 Mar 28:db240370. doi: 10.2337/db24-0370. Online ahead of print.ABSTRACTG protein-coupled receptor 119 (GPR119) is predominantly expressed in pancreatic β-cells, enteroendocrine cells, and the liver. It is a novel therapeutic for dyslipidemia and type 2 diabetes. DA-1241, a GPR119 agon
Diabetes. 2025 Mar 25:db240847. doi: 10.2337/db24-0847. Online ahead of print.ABSTRACTEffective treatment strategies for diabetes-related pain are limited due to its complex pathogenesis, particularly brain mechanisms underlying this disease. The acid-sensing ion channel 1a (ASIC1a) emerges as a key
No abstractDiabetes. 2025 Apr 1;74(4):453. doi: 10.2337/dbi25-0012.NO ABSTRACTPMID:40112157 | DOI:10.2337/dbi25-0012
Diabetes. 2025 Mar 10:db240827. doi: 10.2337/db24-0827. Online ahead of print.ABSTRACTHLA class I (HLA-I) molecules present intracellular antigenic peptides to CD8+ T lymphocytes during immune surveillance. In donors with type 1 diabetes, hyperexpression of HLA-I occurs in islets with residual insul
